Please see below for research outputs and developments relating OnCoRe to date:
Debate: TNT is the new standard of care in locally advanced rectal cancer
Andrew G Renehan, et alSalvage surgery after local regrowth in patients with rectal cancer managed by ‘watch and wait’ following clinical complete response after (chemo)radiotherapy
Kat L Parmar, et al
Presented virtually at the ACP BJS Prize Session
July 2020
Abstract available here
Introducing PrefCoRe: Quantifying and implementing patient preferences for the treatment of high-risk rectal cancer, including the new strategy of organ preservation
Lee Malcomson, et al
Accepted for Poster Presentation at ACPGBI Conference (held virtually), July 2020
Abstract available here
Perineal defect closure and reconstruction in the irradiated field?
Andrew G Renehan
Presented at The Rectal Cancer Conference, Lisbon
February 2020
Management of Patients: Develop a Pre-Treatment Strategy For Risk Assessment and Benefits (ESR 10)
Andrew Renehan, et al
Presented at the Active Monitoring of Cancer AS an alTernative to surgery (CAST) Kick-Off Meeting, Leiden
January 2020
Programme details available here
Watch and wait or surgery for clinical complete response in rectal cancer: a need to study both sides
Kat L Parmar, et al
Colorectal Disease, November 2019
Letter available online here
Salvage surgery after local regrowth in patients with rectal cancer managed by ‘watch and wait’ following clinical complete response after chemoradiotherapy: the OnCoRe study
Kat L Parmar, et al
Poster presentation at ESCP Conference, Vienna
September 2019
Abstract available online here
Is “watch-and-wait” after chemoradiotherapy safe in
patients with rectal cancer?
Fraser M Smith, et al
Uncertainties letter in the BMJ
November 2018
Available online here
Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis
Sam A Chadi, et al
The Lancet Gastroenterology & Hepatology, October 2018
Paper available online here
Survey results of US radiation oncology providers’ contextual
engagement of watch-and-wait beliefs after a complete clinical
response to chemoradiation in patients with local rectal cancer
Jehan Yahya, et al
Journal of Gastrointestinal Oncology
July 2018
Paper available online here
We recently (belatedly) became aware of an interesting paper published in the Journal of Gastrointestinal Oncology, published in 2018, and directly testing familiarity among US Radiology Oncologist of the OnCoRe project. The authors undertook their survey in 2016, shortly after the original OnCoRe publication, and before the IWWD Lancet publication in 2018.
Of the 220 respondents, 48% of respondents supported watchful waiting and 48% claimed familiarity with the OnCoRe Project. Respondents supporting observation were more likely to be familiar with the publication (P=0.029). Among watch-and-wait supporters, 59% felt comfortable discussing this approach and 41% preferred the conversation be initiated by other specialists. There was no association between comfort level in discussing watch-and-wait and familiarity with the OnCoRe Project.”
We are considering updating aspects of this survey among rectal cancer surgeons and oncologists in the UK and Europe.
Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study
The IWWD Consortium
The Lancet Oncology
June 2018
Paper available online here
Oncological Outcome after Salvage Treatment for Local Re-growth following ‘Watch and Wait’ for Clinical Complete Response in Patients with Rectal Cancer
Lee Malcomson, et al
Oral presentation at the ACPGBI, Bournemouth
June 2017
Abstract available online here
Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis
Andrew Renehan, et al
The Lancet Oncology
December 2015
Paper available online here
OnCoRe Plus: The Rectal Cancer Oncological Complete Response Database 