Publications & Presentations

Please see below for research outputs and developments relating OnCoRe to date:

Debate: TNT is the new standard of care in locally advanced rectal cancer

rcr-dlp20Andrew G Renehan, et al
Online debate: RCR2020 Digital Learning Programme
October 2020
Programme available here

Salvage surgery after local regrowth in patients with rectal cancer managed by ‘watch and wait’ following clinical complete response after (chemo)radiotherapy


Kat L Parmar, et al

Presented virtually at the ACP BJS Prize Session

July 2020

Abstract available here

Introducing PrefCoRe: Quantifying and implementing patient preferences for the treatment of high-risk rectal cancer, including the new strategy of organ preservation


Lee Malcomson, et al

Accepted for Poster Presentation at ACPGBI Conference (held virtually), July 2020

Abstract available here

Perineal defect closure and reconstruction in the irradiated field?


Andrew G Renehan

Presented at The Rectal Cancer Conference, Lisbon

February 2020

Management of Patients: Develop a Pre-Treatment Strategy For Risk Assessment and Benefits (ESR 10)

valcoreAndrew Renehan, et al

Presented at the Active Monitoring of Cancer AS an alTernative to surgery (CAST) Kick-Off Meeting, Leiden

January 2020

Programme details available here

Watch and wait or surgery for clinical complete response in rectal cancer: a need to study both sides

letterKat L Parmar, et al

Colorectal Disease, November 2019

Letter available online here

Salvage surgery after local regrowth in patients with rectal cancer managed by ‘watch and wait’ following clinical complete response after chemoradiotherapy: the OnCoRe study

ESCPKat L Parmar, et al

Poster presentation at ESCP Conference, Vienna

September 2019

Abstract available online here

Is “watch-and-wait” after chemoradiotherapy safe in
patients with rectal cancer?


Fraser M Smith, et al

Uncertainties letter in the BMJ

November 2018

Available online here

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis

IntercoreSam A Chadi, et al

The Lancet Gastroenterology & Hepatology, October 2018

Paper available online here

Survey results of US radiation oncology providers’ contextual
engagement of watch-and-wait beliefs after a complete clinical
response to chemoradiation in patients with local rectal cancer


Jehan Yahya, et al

Journal of Gastrointestinal Oncology

July 2018

Paper available online here

We recently (belatedly) became aware of an interesting paper published in the Journal of Gastrointestinal Oncology, published in 2018, and directly testing familiarity among US Radiology Oncologist of the OnCoRe project. The authors undertook their survey in 2016, shortly after the original OnCoRe publication, and before the IWWD Lancet publication in 2018.

Of the 220 respondents, 48% of respondents supported watchful waiting and 48% claimed familiarity with the OnCoRe Project. Respondents supporting observation were more likely to be familiar with the publication (P=0.029). Among watch-and-wait supporters, 59% felt comfortable discussing this approach and 41% preferred the conversation be initiated by other specialists. There was no association between comfort level in discussing watch-and-wait and familiarity with the OnCoRe Project.”

We are considering updating aspects of this survey among rectal cancer surgeons and oncologists in the UK and Europe.

Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study


The IWWD Consortium

The Lancet Oncology

June 2018

Paper available online here

Oncological Outcome after Salvage Treatment for Local Re-growth following ‘Watch and Wait’ for Clinical Complete Response in Patients with Rectal Cancer

BournemouthLee Malcomson, et al

Oral presentation at the ACPGBI, Bournemouth

June 2017

Abstract available online here

Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis


Andrew Renehan, et al

The Lancet Oncology

December 2015

Paper available online here